General Information

  • ID:  hor004444
  • Uniprot ID:  P08610
  • Protein name:  Phyllomedusin
  • Gene name:  NA
  • Organism:  Phyllomedusa bicolor (Two-colored leaf frog) (Rana bicolor)
  • Family:  Tachykinin family
  • Source:  animal
  • Expression:  Expressed by the skin glands.
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Phyllomedusa (genus), Phyllomedusinae (subfamily), Hylidae (family), Hyloidea (superfamily), Neobatrachia (suborder), Anura (order), Batrachia (superorder), Amphibia (class), Tetrapoda, Dipnotetrapodomorpha, Sarcopterygii (superclass), Euteleostomi, Teleostomi, Gnathostomata, Vertebrata, Craniata (subphylum), Chordata (phylum), Deuterostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  NA
  • GO BP:  GO:0006952 defense response; GO:0007218 neuropeptide signaling pathway
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  QNPNRFIGLM
  • Length:  10(1-10)
  • Propeptide:  QNPNRFIGLM
  • Signal peptide:  NA
  • Modification:  T1 Pyrrolidone carboxylic acid;T10 Methionine amide
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  Excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor004444_AF2.pdbhor004444_ESM.pdb

Physical Information

Mass: 135011 Formula: C52H84N16O14S
Absent amino acids: ACDEHKSTVWY Common amino acids: N
pI: 10.55 Basic residues: 1
Polar residues: 3 Hydrophobic residues: 3
Hydrophobicity: -40 Boman Index: -1763
Half-Life: 0.8 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 78
Instability Index: 612 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  5452018
  • Title:  Occurrence of Phyllomedusin, a Physalaemin-Like Decapeptide, in the Skin of Phyllomedusa Bicolor